ClonidineClonidine belongs to a class of medicines known as antihypertensives. It is frequently prescribed to help with the symptoms of opioid withdrawal.

Clonidine works by blocking chemicals in the brain that trigger sympathetic nervous system activity. This reduces uncomfortable symptoms of opioid detoxification, such as sweating, hot flashes, watery eyes and restlessness. Additionally, clonidine has been known to help lower anxiety and may even cut time off the detox process.

"Clonidine can help reduce symptoms of opioid withdrawal, but it is not a cure for opioid addiction by itself."

Medication offers the highest chance of recovery when used in combination with inpatient or outpatient treatment, support groups and professional counseling. Get in touch with a treatment center near you today to get started on your recovery plan.

Uses of Clonidine

Compared to other treatments for an opioid withdrawal, several advantages of clonidine include:

  • It is not a scheduled medication.
  • You can stop using opioids immediately to prepare for naltrexone induction which will assist in preventing relapses.
  • It does not produce the same euphoria as opioids, meaning your need for drugs is reduced.

In the case of alcohol dependence, clonidine is typically combined with benzodiazepine tranquilizers such as Librium, Valium or Xanax.

"The science is clear: Medication-assisted treatment works. There is no easy way."

Paul Coleman, president and CEO at Maryhaven

How Does Clonidine Help Addiction Treatment?

The thought of intense drug cravings and uncomfortable withdrawal symptoms can be intimidating for people with an opioid addiction. Some even start treatment but quickly fall back into old habits at the first signs of withdrawal.

When taking clonidine, however, you are able to better tolerate any withdrawal symptoms you may experience. The medication helps make the process easier to get through, ultimately increasing the chances of continuing past the detoxification stage. After successfully eliminating opioids from your system, you can move on to lasting recovery.

"Medication helps you break free from the ‘hijacking of the brain’ caused by opioids…There’s no wrong door to recovery. This is a highly deadly disease. We need to offer everything that works and not try to dictate the precise recipe for every individual."

Dr. Alexander Walley, director of Addiction Medicine at Boston Medical Center

How is Clonidine Administered?

Clonidine is offered in two forms: a tablet and a patch. Your doctor or addiction treatment specialist will be able to find a solution to best fit your recovery plan.

Clonidine in a tablet form is usually given every few hours on your first day of taking the medicine. Over the next several days, your doses may adjust depending on the withdrawal symptoms you are experiencing. By the end of the week, any signs of withdrawal from your opioid addiction will start to subside. Once this happens, you’ll be tapered off of your clonidine doses until it’s no longer needed.

A treatment program using a clonidine patch will require it to be placed on your skin, generally an area with little hair such as the upper, outer arm or upper chest. After it’s applied on the body, the patch will deliver a constant amount of medication. To accommodate different body sizes, each patch is offered with varying strengths of clonidine. It will take approximately two days for the patch to reach a steady state, so the first couple days of detoxification may entail using the patch and taking a tablet. Medication will be administered over a period of seven days through the patch; however, if withdrawal symptoms continue, your doctor may recommend staying on the patch longer.

"It will take roughly seven days to complete the entire detoxification process while on clonidine."

Both the tablet and patch versions of clonidine require check-ins with your doctor or addiction treatment specialist frequently to have your blood pressure and pulse monitored. Because of this, it’s most effective when used in an inpatient setting so side effects can be observed under close supervision.

Side Effects of Clonidine

Although clonidine helps many people through the opioid detoxification process, it can sometimes lead to unwanted effects. It’s important to notify your doctor if symptoms last longer than they should or become severe.

Some of the side effects you may experience from taking clonidine include:

  • Vomiting
  • Weakness
  • Headache
  • Constipation

Other, but rare side effects of clonidine include:

  • Hives
  • Swelling
  • Rashes
  • Irregular heartbeat
  • Mood changes
  • Breathing problems

Some individuals have also become either addicted to or dependent on clonidine. It’s often looked at as an appealing drug due to its low cost and availability. It’s important to use clonidine as part of a comprehensive treatment program. This helps ensure you don’t fall back into old patterns or rebound to a new addiction.

Clonidine Interactions

Some drugs may cause adverse effects when used with clonidine. Clonidine can also negatively impact some of the drugs you may currently be taking.

Before clonidine is administered, talk with your doctor about any medications you are on. Some of the drugs known to interact with clonidine include:

  •      Blood pressure medications
  •      Heart medications
  •      Antidepressants
  •      Sleeping pills
  •      Anxiety medications
  •      Seizure medications

"Many drugs, including clonidine, can cause adverse effects when taken together. Always check with your healthcare provider about possible interactions between medications."

Where is Clonidine Available?

A prescription is needed to obtain clonidine. Consult your doctor or addiction treatment specialist about proper dosing information, potential harmful side effects and frequency before taking clonidine.

Clonidine has been around for more than 40 years and has many uses for different health conditions. Along with treating opioid withdrawal symptoms, it is also commonly used for:

  • Migraine
  • Diarrhea
  • Pain conditions
  • High blood pressure
  • Attention deficit hyperactivity disorder (ADHD)
  • Anxiety disorders

If you or someone you care about is struggling with an opioid addiction, clonidine can help minimize the withdrawal symptoms from quitting. Get in touch with us today to find a treatment center that administers clonidine.

Clonidine Statistics



Medications are used in nearly 80 percent of detoxifications in treatment facilities.




The detoxification stage lasts approximately seven days while taking clonidine.




There are four treatment steps to sobriety: intake, detoxification, rehabilitation and ongoing recovery.


Don’t Let Life Pass You By

If you are interested in investigating the possibly benefits of Clonidine in treating your substance abuse disorder, or that of a loved one, the time to start is now. There are dedicated treatment experts on the line waiting for you to reach out. Contact one now to start putting your life back together.

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